Open Systems Pharmacology

Big Brother Mod By Smirniy Version 20 Final Exclusive __full__ Jun 2026

Reliable, powerful and easy-to-use modeling & simulation tools for pharmaceutical and other life-sciences applications. Qualified and accepted by the scientific community including academia, regulatory agencies and industry. Available free to everyone.

Essentials

Download OSP Suite

Explore the full functionality of the OSP suite. PBPK, PBPK/PD, QSP – the OSP Suite gives you the flexibility to build it all without having to start from scratch.

Forum

Have your questions answered or provide answers to others. The Forum is a great way to stay up-to-date on the community buzz around OSP.

Documentation

Need to find out how to use a feature? Looking to understand the inner workings of the model? Here you’ll find the extensive OSP manual and qualification documents.

News & Release

Save the Date: OSP Community Conference 2026

In Beerse, Antwerp September 24th and 25th

Open Systems Pharmacology Suite - Version 12 Update 2

We are pleased to announce the new release of the OSP Suite Version 12 Update 2 which is now available for download.

WORKSHOP AT ACOP COLORADO.

Join ESQlabs at the ACoP Conference in Colorado Building Scalable PBPK-QSP Models - Modularization in MoBi for OSP Suite V12.

Ready to take the plunge? Download

Big Brother Mod By Smirniy Version 20 Final Exclusive __full__ Jun 2026

Over the years, Smirniy released multiple iterations, updating graphics, refining mechanics, and fixing bugs. Version 20 Final Exclusive is the absolute end of this development pipeline. It incorporates all previous patches, fan-requested fixes, and exclusive content that was previously locked in private testing builds. Key Features of Version 20 Final Exclusive

: The mod explores the strong bond between Boyfriend and BB, showing BB's protective nature and his internal struggle with trauma following his revival. Version 2.0 Features

This public link is valid for 7 days and shares a thread, including any personal information you added. This link or copies made by others cannot be deleted. If you share with third parties, their policies apply. Can’t copy the link right now. Try again later. Big Brother Mod v0.20: Gameplay Events | PDF - Scribd big brother mod by smirniy version 20 final exclusive

Locate your existing Big Brother save folder and copy it to a secure secondary directory.

Hunger, thirst, radiation, and exhaustion are your primary enemies. Key Features of Version 20 Final Exclusive :

The "Final Exclusive" or 2.0 update significantly expanded the mod's content:

The Big Brother mod by Smirniy is a comprehensive mod for RimWorld that aims to revamp the game's UI, add new features, and improve overall gameplay. The mod is designed to provide a more immersive and engaging experience, with a focus on storytelling, role-playing, and strategic gameplay. If you share with third parties, their policies apply

Nighttime is pitch black, making a flashlight, night-vision goggles (NVG), or a burning flare absolute necessities for survival.

Do you need a guide on or faction walkthroughs?

This public link is valid for 7 days and shares a thread, including any personal information you added. This link or copies made by others cannot be deleted. If you share with third parties, their policies apply. Can’t copy the link right now. Try again later.

Built on an improved engine (often utilizing the OGSR engine or similar forks), providing better memory management and 64-bit support to prevent the "random crashes" common in older versions.

Publications & Models

Models

Glucose Insulin Model

Scientifically exciting for diabetes researchers. Technically exciting for everyone with PBPK models of glucose, insulin, and glucagon coupled through non-mechanistic PD as well as systems pharmacology PD models.

Publications

Journal Publications

Growing list of scientific journal publications that relates to OSP or describes work with PK-Sim® or MoBi®. Add your own contributions and label them or others appropriately to further grow and structure this database.

Take a look at all our models Browse

Management Team

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